Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM248940
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.03±n/a nM
Comments
extracted
Citation
 Do, S; Hu, H; Kolesnikov, A; Tsui, VH; Wang, X 5-azaindazole compounds and methods of use US Patent  US9434725 Publication Date 9/6/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM248940
Synonyms:
US9434725, 171 | US9434725, 182 | US9434725, 183
Type:
Small organic molecule
Emp. Form.:
C22H24N8
Mol. Mass.:
400.4796
SMILES:
CC1CCC(N)CN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Structure:
Search PDB for entries with ligand similarity: