Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM248938
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.035±n/a nM
Comments
extracted
Citation
 Do, S; Hu, H; Kolesnikov, A; Tsui, VH; Wang, X 5-azaindazole compounds and methods of use US Patent  US9434725 Publication Date 9/6/2016 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM248938
Synonyms:
US9434725, 169 | US9434725, 185 | US9434725, 193
Type:
Small organic molecule
Emp. Form.:
C21H22N8
Mol. Mass.:
386.453
SMILES:
CC1CN(CCN1)c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1
Structure:
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