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TargetBeta-secretase 2 (BACE2)
LigandBDBM249095
Substrate/Competitorn/a
Meas. Tech.Time-Resolved Endpoint Proteolysis Assay
Ki 0.9±n/a nM
Citation Gilbert, EJCumming, JNScott, JDWu, WBurnett, DAStamford, AW C2-azaspiro iminothiazine dioxides as BACE inhibitors, compositions, and their use US Patent US9453034 Publication Date 9/27/2016
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 2 (BACE2)
Name:Beta-secretase 2 (BACE2)
Synonyms:ASP1 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | Beta secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:Enzyme
Mol. Mass.:56171.20
Organism:Homo sapiens (human)
Description:n/a
Residue:518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM249095
NameBDBM249095
Synonyms:US9453034, 9
TypeSmall organic molecule
Emp. Form.C22H26FN5O4S
Mol. Mass.475.536
SMILESCOc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(C)CS(=O)(=O)C3(CN(C)C3)C(=N)N2)c(C)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a