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Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM249273
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
200.6±n/a nM
Comments
extracted
Citation
 Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent  US9458145 Publication Date 10/4/2016 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM249273
Synonyms:
US10017501, Compound 1020-1 | US9458145, 1020-1
Type:
Small organic molecule
Emp. Form.:
C21H27N5O3S
Mol. Mass.:
429.536
SMILES:
Cc1noc(C)c1-c1cc(c2nc(NCC3CC3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Structure:
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