Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM249294
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
121.0±n/a nM
Comments
extracted
Citation
Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016
More Info.:
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
Inhibitor
Name:
BDBM249294
Synonyms:
US10017501, Compound 1020-90 | US9458145, 1020-90
Type:
Small organic molecule
Emp. Form.:
C23H20N4O2
Mol. Mass.:
384.4305
SMILES:
COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12 |(-5.25,-5,;-3.71,-5,;-2.94,-3.66,;-1.41,-3.5,;-1.09,-1.99,;.25,-1.22,;.25,.32,;-1.09,1.09,;-2.42,.32,;-2.42,-1.22,;-3.56,-2.25,;-1.09,2.63,;.16,3.53,;1.49,2.76,;-.32,5,;-1.86,5,;-2.33,3.53,;-3.67,2.76,;1.58,-1.99,;1.98,-3.48,;.89,-4.57,;3.47,-3.88,;4.56,-2.79,;4.16,-1.3,;5.25,-.22,;4.85,1.27,;3.36,1.67,;2.27,.58,;2.67,-.91,)|