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Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM249295
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
102.0±n/a nM
Comments
extracted
Citation
 Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent  US9458145 Publication Date 10/4/2016 
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM249295
Synonyms:
US10017501, Compound 1020-92 | US9458145, 1020-92
Type:
Small organic molecule
Emp. Form.:
C23H17F3N4O
Mol. Mass.:
422.4025
SMILES:
Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(F)(F)F |(.56,2.76,;-.78,3.53,;-1.25,5,;-2.79,5,;-3.27,3.53,;-4.6,2.76,;-2.02,2.63,;-2.02,1.09,;-.69,.32,;-.69,-1.22,;.64,-1.99,;.64,-3.53,;-.69,-4.3,;1.98,-4.3,;3.31,-3.53,;3.31,-1.99,;4.65,-1.22,;4.65,.32,;3.31,1.09,;1.98,.32,;1.98,-1.22,;-2.02,-1.99,;-2.34,-3.5,;-3.88,-3.66,;-4.5,-2.25,;-3.36,-1.22,;-3.36,.32,;-4.65,-5,;-6.19,-5,;-5.42,-6.33,;-3.56,-6.08,)|
Structure:
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