Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)
LigandBDBM249283
Substrate/Competitorn/a
Meas. Tech.Amplified Luminescent Proximity Homogeneous Assay (ALPHA)
pH7.5±n/a
Temperature298.15±n/a K
IC50 22.6±n/a nM
Commentsextracted
Citation Aktoudianakis, EChin, GCorkey, BKDu, JElbel, KJiang, RHKobayashi, TLee, RMartinez, RMetobo, SEMish, MMunoz, MShevick, SSperandio, DYang, HZablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 Publication Date 10/4/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)
Name:Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)
Synonyms:Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1
Type:n/a
Mol. Mass.:8856.55
Organism:Homo sapiens (Human)
Description:BD1 (75-147 aa) of O60885
Residue:73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFT
NCYIYNKPGDDIV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM249283
NameBDBM249283
Synonyms:US9458145, 1020-57
TypeSmall organic molecule
Emp. Form.C22H22N4O
Mol. Mass.358.4363
SMILESCc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2[nH]c(nc2c1)C1CC1 |(1.89,3.53,;.56,4.3,;.08,5.77,;-1.46,5.77,;-1.94,4.3,;-3.27,3.53,;-.69,3.4,;-.69,1.86,;.64,1.09,;.64,-.45,;1.98,-1.22,;1.98,-2.76,;.64,-3.53,;3.31,-3.53,;4.65,-2.76,;4.65,-1.22,;3.31,-.45,;3.31,1.09,;-.69,-1.22,;-1.01,-2.73,;-2.54,-2.89,;-3.17,-1.48,;-2.02,-.45,;-2.02,1.09,;-3.31,-4.23,;-4.65,-5,;-3.31,-5.77,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a