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Target
Galactokinase
Ligand
BDBM249843
Substrate
n/a
Meas. Tech.
qHTS Assay
IC50
3658.8±n/a nM
Citation
 Boxer, MB; Walsh, MJ; Liu, L; Tanega, CD; Shen, M; Lai, K; Tang, M; Auld, DS Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders US Patent  US9447087 Publication Date 9/20/2016 
Target
Name:
Galactokinase
Synonyms:
GALK | GALK1 | GALK1_HUMAN | Galactokinase | Galactokinase (GALK) | Galactose kinase
Type:
Enzyme
Mol. Mass.:
42271.26
Organism:
Homo sapiens (Human)
Description:
P51570
Residue:
392
Sequence:
MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
  
Inhibitor
Name:
BDBM249843
Synonyms:
US9447087, 80
Type:
Small organic molecule
Emp. Form.:
C26H22BrN5O3
Mol. Mass.:
532.389
SMILES:
COc1ccccc1NC(=O)C1=C(C)NC(Nc2nc3ccccc3o2)=NC1c1ccccc1Br |c:12,28|
Structure:
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