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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM250460
Substrate/Competitorn/a
Meas. Tech.HTRF Assay
pH6±n/a
Temperature298.15±n/a K
IC50 0.12±n/a nM
Commentsextracted
Citation Ahn, SKAuh, JChoi, NSHan, CKKim, TPae, KShin, YJHan, DHan, CK Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient US Patent US9464044 Publication Date 10/11/2016
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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  Blast E-value cutoff:
BDBM250460
NameBDBM250460
Synonyms:US9464044, 62
TypeSmall organic molecule
Emp. Form.C22H28ClN3O4S
Mol. Mass.465.993
SMILESCN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1 |r,wU:8.8,TLB:18:15:8:12.11.10,7:8:12:15.16.14,17:15:12:8.9.10,THB:16:15:8:12.11.10,16:11:8:15.17.14,17:9:12:15.16.14,(-1.95,-1.73,;-1.95,-.19,;-.62,.58,;.15,1.91,;-1.39,1.91,;.72,-.19,;.72,-1.73,;2.05,.58,;3.38,-.19,;4.72,.58,;3.96,-.59,;3.94,-2.99,;2.55,-3.63,;3.38,-1.73,;4.72,-2.5,;6.04,-1.73,;5.15,-3.66,;6.04,-.19,;7.53,-2.13,;8.62,-1.04,;7.93,-3.62,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-4.62,2.89,;-5.95,3.66,;-7.29,2.89,;-7.29,1.35,;-8.62,.58,;-5.95,.58,)|
Structure
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