Reaction Details
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Serine/threonine-protein kinase mTOR [1360-2549]
Ligand
BDBM251578
Substrate
n/a
Meas. Tech.
LanthaScreen Kinase Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
146±n/a nM
Comments
extracted
Citation
Pastor Fernández, J; Fernández-Capetillo Ruiz, O; Martínez González, S; Blanco Aparicio, C; Rico Ferreira, M; Toledo Lázaro, LI; Rodríguez Arísteguí, S; Murga Costa, M; Varela Busto, C; Lopez Contreras, AJ; Renner, O; Nieto Soler, M; Cebrián Muñoz, DA Chemical entities US Patent US9453031 Publication Date 9/27/2016 More Info.:
Target
Name:
Serine/threonine-protein kinase mTOR [1360-2549]
Synonyms:
FRAP | FRAP1 | FRAP2 | MTOR | MTOR_HUMAN | RAFT1 | RAPT1 | Serine/threonine-protein kinase mTOR
Type:
Enzyme
Mol. Mass.:
136306.16
Organism:
Homo sapiens (Human)
Description:
aa 1360-2549
Residue:
1190
Sequence:
LAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
Inhibitor
Name:
BDBM251578
Synonyms:
US9453031, 1
Type:
Small organic molecule
Emp. Form.:
C21H24N4O4S
Mol. Mass.:
428.505
SMILES:
CC(C)(c1nc(nc2N3CCOCC3COc12)-c1cccc2[nH]ccc12)S(C)(=O)=O
Structure:
