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Target
Neutrophil elastase
Ligand
BDBM251833
Substrate
US9475779, MeOSuc-Ala-Ala-Pro-Val-AMC
Meas. Tech.
Human Neutrophil Elastase Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
101±n/a nM
Comments
extracted
Citation
 Oost, T; Anderskewitz, R; Gnamm, C; Hoesch, H; Morschhaeuser, G; Peters, S; Ries, UJ Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent  US9475779 Publication Date 10/25/2016 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM251833
Synonyms:
US9475779, D.2.3
Type:
Small organic molecule
Emp. Form.:
C20H15BrN4O4S
Mol. Mass.:
487.326
SMILES:
CS(=O)(=O)c1cc(ccc1C1NC(=O)N(C2=C1C(=O)CC2)c1cncc(Br)c1)C#N |c:16|
Structure:
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Substrate
Name:
BDBM211682
Synonyms:
US9290457, MeOSuc-AAPV-AMC
Type:
Substrate
Emp. Form.:
C31H41N5O9
Mol. Mass.:
627.6853
SMILES:
COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc1ccc2c(C)cc(=O)oc2c1
Structure:
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