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Target
Complement factor B
Ligand
BDBM251868
Substrate
n/a
Meas. Tech.
Biological Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
290±n/a nM
Comments
extracted
Citation
 Adams, CM; Babu, C; Capparelli, MP; Ding, J; Ehara, T; Jendza, K; Ji, N; Karki, RG; Kawanami, T; Xue, L; Mainolfi, N; Powers, JJ; Serrano-Wu, MH; Zhang, C Complement factor B inhibitors and uses there of US Patent  US9475806 Publication Date 10/25/2016 
Target
Name:
Complement factor B
Synonyms:
BF | BFD | CFAB_HUMAN | CFB
Type:
Enzyme
Mol. Mass.:
85537.97
Organism:
Homo sapiens (Human)
Description:
P00751
Residue:
764
Sequence:
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
  
Inhibitor
Name:
BDBM251868
Synonyms:
US9475806, 5-B b) (+)
Type:
Small organic molecule
Emp. Form.:
C19H15F3N6O
Mol. Mass.:
400.3572
SMILES:
COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F
Structure:
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