Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM252454
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
IC50
340±n/a nM
Comments
extracted
Citation
 Bair, KWBaumeister, TRDragovich, PGosselin, FYuen, PZak, MZheng, X Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives US Patent  US9458172 Publication Date 10/4/2016 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM252454
Synonyms:
US9458172, 25 | US9458172, 28 | US9458172, 29
Type:
Small organic molecule
Emp. Form.:
C20H13F2N3O3S
Mol. Mass.:
413.397
SMILES:
Fc1cc(F)cc(c1)S(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Structure:
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