Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM252531
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
IC50
0.99±n/a nM
Comments
extracted
Citation
 Bair, KW; Baumeister, TR; Dragovich, P; Gosselin, F; Yuen, P; Zak, M; Zheng, X Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives US Patent  US9458172 Publication Date 10/4/2016 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM252531
Synonyms:
US9458172, 112 | US9458172, 133
Type:
Small organic molecule
Emp. Form.:
C22H19N3O6S
Mol. Mass.:
453.468
SMILES:
COc1cc(OC)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
Structure:
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