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Target
Kappa-type opioid receptor
Ligand
BDBM50014995
Substrate
n/a
Meas. Tech.
Ligand Binding Assay
pH
7.4±n/a
Ki
4.4±n/a nM
Comments
extracted
Citation
 Lewis, J; Husbands, S Orvinol and thevinol derivatives useful in the treatment of anxiety or a compulsive disorder US Patent  US9480684 Publication Date 11/1/2016 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50014995
Synonyms:
CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9480684, 13a, R = Ph- BU126
Type:
Small organic molecule
Emp. Form.:
C30H35NO4
Mol. Mass.:
473.6032
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@]([H])(C1)[C@H](O)c1ccccc1)ccc3O |r,THB:10:9:17:4.5.6|
Structure:
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