Reaction Details Report a problem with these data
Target
Cholinesterase
Ligand
BDBM294225
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
12700±n/a nM
Citation
Gulcan, HO; Unlu, S; Esiringu, I; Sahin, Y; Ercetin, T; Oz, D; Sahin, F 1-(dimethylamino)ethyl-substituted 6H-benzo[C]chromen-6-ones against senile dementia US Patent US9586925 Publication Date 3/7/2017
More Info.:
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
Inhibitor
Name:
BDBM294225
Synonyms:
(±)-3-(1-(dimethylamino)ethyl)-6-oxo-6H-benzo[c]chromen-1-yl ethyl(methyl)carbamate | US9586925, Compound FAR-01-2CA | US9586925, EXAMPLE XIX
Type:
Small organic molecule
Emp. Form.:
C21H24N2O4
Mol. Mass.:
368.4263
SMILES:
CCN(C)C(=O)Oc1cc(cc2oc(=O)c3ccccc3c12)C(C)N(C)C