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Target
Isoform 6 of Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A1)
Ligand
BDBM253042
Substrate
n/a
Meas. Tech.
Inhibtion Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
>10000±n/a nM
Comments
extracted
Citation
 Cutshall, NS; Ferguson, KM; Zuta, CP Optically active PDE10 inhibitor US Patent  US9493447 Publication Date 11/15/2016 
Target
Name:
Isoform 6 of Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A1)
Synonyms:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A1) | PDE1A | PDE1A_HUMAN | Phosphodiesterase 1A
Type:
Enzyme
Mol. Mass.:
60643.90
Organism:
Homo sapiens (Human)
Description:
P54750-6
Residue:
529
Sequence:
MDDHVTIRKKHLQRPIFRLRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKHDETHS
  
Inhibitor
Name:
BDBM253042
Synonyms:
US9493447, 1001
Type:
Small organic molecule
Emp. Form.:
C25H23ClN2O5S
Mol. Mass.:
498.979
SMILES:
CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1
Structure:
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