Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM253117
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
Temperature
298.15±n/a K
IC50
37±n/a nM
Comments
extracted
Citation
 Duan, J; Dhar, TG; Jiang, B; Lu, Z; Xiao, H Pyrrolidinyl sulfone RORγ modulators US Patent  US9458171 Publication Date 10/4/2016 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM253117
Synonyms:
US9458171, 77
Type:
Small organic molecule
Emp. Form.:
C26H24F10N2O5S
Mol. Mass.:
666.528
SMILES:
OC(c1ccc(cc1)[C@@]1(CCN(C1)C(=O)N1CCC(O)(CC1)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F |r|
Structure:
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