Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM135633
Substrate
n/a
Meas. Tech.
Competitive Inhibition Assay Using [I125]-NDP-a-MSH
pH
7.5±n/a
Temperature
310.15±n/a K
Ki
12±n/a nM
Comments
extracted
Citation
 Shi, Y; Sharma, SD; Dodd, JH; Yang, W Melanocortin receptor-specific heptapeptides US Patent  US9458201 Publication Date 10/4/2016 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM135633
Synonyms:
US10179804, Example 18 | US10632171, Peptide No. 18 | US8846601, 18 | US9458201, 55
Type:
Small organic molecule
Emp. Form.:
C56H76N16O9
Mol. Mass.:
1117.3044
SMILES:
CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](Cc3ccccc3)CN2C1=O)C(N)=O |r|
Structure:
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