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TargetCholesteryl ester transfer protein
LigandBDBM254028
Substrate/Competitorn/a
Meas. Tech.Cholesteryl Ester Transfer Assay
IC50 5.8±n/a nM
Citation Lee, JKOh, JTLee, JWLee, SHKim, ILee, JYBae, SYLee, SRKim, YT Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors US Patent US9493430 Publication Date 11/15/2016
More Info.:Get all data from this article,  Assay Method
 
Cholesteryl ester transfer protein
Name:Cholesteryl ester transfer protein
Synonyms:Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:Enzyme
Mol. Mass.:54751.53
Organism:Homo sapiens (Human)
Description:P11597
Residue:493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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  Blast E-value cutoff:
BDBM254028
n/a
NameBDBM254028
Synonyms:US9493430, 554
TypeSmall organic molecule
Emp. Form.C36H35F6NO5
Mol. Mass.675.6572
SMILESCOc1ccc(cc1C1=C(CN2[C@@H](C)[C@H](OC2=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)CC(C)(C)CC1)-c1ccc(cc1C)C(O)=O |r,c:9|
Structure
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