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Target
Cholesteryl ester transfer protein
Ligand
BDBM254066
Substrate
n/a
Meas. Tech.
Cholesteryl Ester Transfer Assay
IC50
5.9±n/a nM
Citation
 Lee, JK; Oh, JT; Lee, JW; Lee, SH; Kim, I; Lee, JY; Bae, SY; Lee, SR; Kim, YT Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors US Patent  US9493430 Publication Date 11/15/2016 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM254066
Synonyms:
US9493430, 756
Type:
Small organic molecule
Emp. Form.:
C37H34F10N2O3
Mol. Mass.:
744.6615
SMILES:
CCNC(=O)c1ccc(-c2ccc(F)c(c2)C2=C(CN3[C@@H](C)[C@H](OC3=O)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)CC(C)(C)CC2)c(c1)C(F)(F)F |r,c:17|
Structure:
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