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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM254095
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
2404±n/a nM
Comments
extracted
Citation
 Walsh, SP; Pasternak, A; Shi, Z; Cato, B; Kim, EY Inhibitors of the renal outer medullary potassium channel US Patent  US9493474 Publication Date 11/15/2016 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM254095
Synonyms:
US9493474, 7B
Type:
Small organic molecule
Emp. Form.:
C25H28N4O4
Mol. Mass.:
448.5142
SMILES:
Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCC2CN(CC(O)c3ccc(cn3)C#N)CC12 |r|
Structure:
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