Target
Complement factor D
Ligand
BDBM254429
Substrate
n/a
Meas. Tech.
Human Complement Factor D Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
259±n/a nM
Comments
extracted
Citation
 Altmann, EHommel, ULorthiois, ELMaibaum, JKOstermann, NQuancard, JRandl, SARogel, OVulpetti, A Pyrrolidine derivatives and their use as complement pathway modulators US Patent  US9468661 Publication Date 10/18/2016 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM254429
Synonyms:
US9468661, 7
Type:
Small organic molecule
Emp. Form.:
C22H27N5O3
Mol. Mass.:
409.4815
SMILES:
CC1CC(CNC(=O)[C@@H]2C[C@H]3C[C@H]3N2C(=O)Cn2nc(C(C)=O)c3ccncc23)C1 |r,wU:8.7,wD:10.10,12.11,(6.72,6.9,;5.63,5.81,;5.63,4.27,;4.09,4.27,;3,3.18,;1.52,3.58,;.43,2.49,;.82,1.01,;-1.06,2.89,;-1.54,4.36,;-3.08,4.36,;-4.58,4.04,;-3.55,2.89,;-2.31,1.99,;-2.31,.45,;-.97,-.32,;-3.64,-.32,;-3.64,-1.86,;-4.89,-2.77,;-4.41,-4.23,;-5.18,-5.57,;-4.41,-6.9,;-6.72,-5.57,;-2.87,-4.23,;-1.84,-5.38,;-.33,-5.06,;.14,-3.59,;-.89,-2.45,;-2.39,-2.77,;4.09,5.81,)|
Structure:
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