Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM254647
Substrate
n/a
Meas. Tech.
LANCE cAMP Assay
Temperature
310.15±n/a K
EC50
42±n/a nM
Comments
extracted
Citation
 Nosse, B; Blum, A; Heckel, A; Himmelsbach, F; Ashweek, NJ; Harriott, N N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof US Patent  US9469631 Publication Date 10/18/2016 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM254647
Synonyms:
US9469631, 48
Type:
Small organic molecule
Emp. Form.:
C21H25F2N5O3
Mol. Mass.:
433.4517
SMILES:
CC(C)OC(=O)N1CC[C@@H]([C@H](F)C1)N(C1CC1)C(=O)c1ccc(c(F)c1)-n1cncn1 |r|
Structure:
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