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TargetBRD4 BD1 (aa 42-168)
LigandBDBM254915
Substrate/Competitorn/a
Meas. Tech.AlphaLisa Binding Assay
pH7±n/a
Temperature298.15±n/a K
IC50 28±n/a nM
Commentsextracted
Citation Albrecht, BKHewitt, MCGehling, VSVaswani, RG Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof US Patent US9493483 Publication Date 11/15/2016
More Info.:Get all data from this article,  Assay Method
 
BRD4 BD1 (aa 42-168)
Name:BRD4 BD1 (aa 42-168)
Synonyms:Bromodomain-containing protein 4 Bromo Domain 1
Type:Enzyme Catalytic Domain
Mol. Mass.:15054.68
Organism:Homo sapiens (Human)
Description:n/a
Residue:127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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  Blast E-value cutoff:
BDBM254915
NameBDBM254915
Synonyms:US9493483, 403
TypeSmall organic molecule
Emp. Form.C26H21ClN4O2
Mol. Mass.456.924
SMILESCc1noc2[C@H](CC(N)=O)N=C(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1ccc(C)nc1 |r,t:10|
Structure
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n/a