Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM254917
Substrate
n/a
Meas. Tech.
AlphaLisa Binding Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
175±n/a nM
Comments
extracted
Citation
 Albrecht, BK; Hewitt, MC; Gehling, VS; Vaswani, RG Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof US Patent  US9493483 Publication Date 11/15/2016 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM254917
Synonyms:
US9493483, 405
Type:
Small organic molecule
Emp. Form.:
C24H19ClN4O3
Mol. Mass.:
446.886
SMILES:
Cc1noc2[C@H](CC(O)=O)N=C(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1cnn(C)c1 |r,t:10|
Structure:
Search PDB for entries with ligand similarity: