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Target
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM294238
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
<10.00±n/a nM
Citation
 Amberg, W; Pohlki, F; Lange, U; Wang, Y; Brewer, J; Vasudevan, A; Lao, Y; Hutchins, C; Zhao, H; Li, H Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9586942 Publication Date 3/7/2017 
Target
Name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:
PROTEIN
Mol. Mass.:
50891.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107587
Residue:
445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
  
Inhibitor
Name:
BDBM294238
Synonyms:
N-((1R,3r)-3-((7S,8R)-7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclobutyl)-1-methyl-1H-imidazole-4-sulfonamide | US9586942, 12
Type:
Small organic molecule
Emp. Form.:
C28H34N4O2S
Mol. Mass.:
490.66
SMILES:
Cn1cnc(c1)S(=O)(=O)N[C@H]1C[C@@H](C1)c1ccc2CC[C@@H]([C@H](Cc3ccccc3)c2c1)N1CCC1 |r,wU:12.15,20.35,21.23,wD:10.10,(-4.24,5.86,;-5.01,4.53,;-6.55,4.53,;-7.03,3.06,;-5.78,2.16,;-4.54,3.06,;-5.78,.62,;-4.24,.62,;-7.32,.62,;-5.78,-.92,;-4.45,-1.69,;-4.05,-3.18,;-2.56,-2.78,;-2.96,-1.29,;-1.23,-3.55,;-1.23,-5.09,;.1,-5.86,;1.44,-5.09,;2.77,-5.86,;4.1,-5.09,;4.1,-3.55,;2.77,-2.78,;2.77,-1.24,;1.44,-.47,;.1,-1.24,;-1.23,-.47,;-1.23,1.07,;.1,1.84,;1.44,1.07,;1.44,-3.55,;.1,-2.78,;5.44,-2.78,;6.93,-3.18,;7.32,-1.69,;5.84,-1.29,)|
Structure:
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