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Target
Tyrosine-protein kinase SYK
Ligand
BDBM255526
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
66.5±n/a nM
Comments
extracted
Citation
 Singh, R; Argade, A; Payan, DG; Molineaux, S; Holland, SJ; Clough, J; Keim, H; Bhamidipati, S; Sylvain, C; Li, H; Rossi, AB 2,4-pyrimidinediamine compounds and their uses US Patent  US9499493 Publication Date 11/22/2016 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM255526
Synonyms:
N4-(3-Methylcarbonyloximephenyl)-5-fluoro-N2-[3-(N-methylamino)carbonylmethyleneoxyphenyl]-2,4-pyrimidinediamine | US9499493, R950373
Type:
Small organic molecule
Emp. Form.:
C22H25FN6O4
Mol. Mass.:
456.4701
SMILES:
CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3cccc(c3)C(=O)NOC)n2)=C1 |c:6,33|
Structure:
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