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Target
Fibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P
Ligand
BDBM255631
Substrate
n/a
Meas. Tech.
High ATP Kinase Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
15.6±n/a nM
Comments
extracted
Citation
 Lobell, M; Hübsch, W; Schirok, H; Héroult, M; Brohm, D; Collin, M; Grünewald, S; Lustig, K; Bömer, U; Voehringer, V; Lindner, N Substituted benzothienyl-pyrrolotriazines and uses thereof US Patent  US9475815 Publication Date 10/25/2016 
Target
Name:
Fibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P
Synonyms:
GST-Fibroblast growth factor receptor 1 (FGFR-1)
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glutathione S-transferase P
Synonyms:
FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Homo sapiens (Human)
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
  
Component 2
Name:
Fibroblast growth factor receptor 1 [400-800]
Synonyms:
BFGFR | CEK | FGFBR | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor 1 (FGFR-1) | HBGFR
Type:
Protein
Mol. Mass.:
45097.70
Organism:
Homo sapiens (Human)
Description:
aa 400-800
Residue:
401
Sequence:
KSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEP
  
Inhibitor
Name:
BDBM255631
Synonyms:
US9475815, 16
Type:
Small organic molecule
Emp. Form.:
C23H28N6OS
Mol. Mass.:
436.573
SMILES:
CCN[C@H]1CCN(Cc2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnn23)C1 |r|
Structure:
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