Target
Fibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P
Ligand
BDBM255711
Substrate
n/a
Meas. Tech.
High ATP Kinase Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
12.6±n/a nM
Comments
extracted
Citation
 Lobell, MHübsch, WSchirok, HHéroult, MBrohm, DCollin, MGrünewald, SLustig, KBömer, UVoehringer, VLindner, N Substituted benzothienyl-pyrrolotriazines and uses thereof US Patent  US9475815 Publication Date 10/25/2016 
Target
Name:
Fibroblast growth factor receptor 1 [400-80]/Glutathione S-transferase P
Synonyms:
GST-Fibroblast growth factor receptor 1 (FGFR-1)
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glutathione S-transferase P
Synonyms:
FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Homo sapiens (Human)
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
  
Component 2
Name:
Fibroblast growth factor receptor 1 [400-800]
Synonyms:
BFGFR | CEK | FGFBR | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor 1 (FGFR-1) | HBGFR
Type:
Protein
Mol. Mass.:
45097.70
Organism:
Homo sapiens (Human)
Description:
aa 400-800
Residue:
401
Sequence:
KSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEP
  
Inhibitor
Name:
BDBM255711
Synonyms:
US9475815, 96
Type:
Small organic molecule
Emp. Form.:
C23H26N6O3S
Mol. Mass.:
466.556
SMILES:
COc1cc(C)cc2cc(sc12)-c1cc(CN2CCN(CC2)C(=O)CO)n2ncnc(N)c12
Structure:
Search PDB for entries with ligand similarity: