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Target
Fibroblast growth factor receptor 3 [397-806]/Glutathione S-transferase P
Ligand
BDBM255706
Substrate
n/a
Meas. Tech.
TR-FRET Based Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
23.9±n/a nM
Comments
extracted
Citation
 Lobell, M; Hübsch, W; Schirok, H; Héroult, M; Brohm, D; Collin, M; Grünewald, S; Lustig, K; Bömer, U; Voehringer, V; Lindner, N Substituted benzothienyl-pyrrolotriazines and uses thereof US Patent  US9475815 Publication Date 10/25/2016 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]/Glutathione S-transferase P
Synonyms:
GST-Fibroblast growth factor receptor 3 (FGFR-3)
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Glutathione S-transferase P
Synonyms:
FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | GSTP1_HUMAN | Glutathione S-transferase | Glutathione S-transferase (GST) | Glutathione S-transferase P | Glutathione S-transferase Pi | Glutathione transferase (GST)
Type:
Enzyme
Mol. Mass.:
23353.53
Organism:
Homo sapiens (Human)
Description:
P09211
Residue:
210
Sequence:
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ
  
Component 2
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM255706
Synonyms:
US9475815, 91
Type:
Small organic molecule
Emp. Form.:
C20H21N5O2S
Mol. Mass.:
395.478
SMILES:
COc1cc(C)cc2cc(sc12)-c1cc(CN2CC(O)C2)n2ncnc(N)c12
Structure:
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