Reaction Details Report a problem with these data
Target
chymase
Ligand
BDBM256113
Substrate
n/a
Meas. Tech.
Enzymatic Chymase Assay
pH
7.5±n/a
IC50
3±n/a nM
Comments
extracted
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M; Börngen, K Bicyclically substituted uracils and the use thereof US Patent  US9481672 Publication Date 11/1/2016 
Target
Name:
chymase
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
27507.42
Organism:
Mesocricetus auratus (Golden hamster)
Description:
A0A1U7QTH6
Residue:
247
Sequence:
MLLPALRLLLFLLGSSAEAGKIIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNFVMTAAHCAGRSITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDHLVLNDIMLLKLKEKANLTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILDPQACKHFEDFHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVLRNAKPPSVFTRISHYRPWINKILREN
  
Inhibitor
Name:
BDBM256113
Synonyms:
US9481672, 296
Type:
Small organic molecule
Emp. Form.:
C24H18F3N3O5S
Mol. Mass.:
517.477
SMILES:
Cn1c2ccc(cc2sc1=O)-n1cc(C(O)=O)c(=O)n(C2CCCc3c2cccc3C(F)(F)F)c1=O
Structure:
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