Reaction Details Report a problem with these data
Target
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM294268
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
<10.00±n/a nM
Citation
 Amberg, W; Pohlki, F; Lange, U; Wang, Y; Brewer, J; Vasudevan, A; Lao, Y; Hutchins, C; Zhao, H; Li, H Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9586945 Publication Date 3/7/2017 
Target
Name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:
PROTEIN
Mol. Mass.:
50891.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107587
Residue:
445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
  
Inhibitor
Name:
BDBM294268
Synonyms:
trans-N-(1-(4-benzyl-7-fluoro-3-(methylamino)chroman-6-yl)azetidin-3-yl)-1-cyclopropylmethanesulfonamide | US9586945, 19b
Type:
Small organic molecule
Emp. Form.:
C24H30FN3O3S
Mol. Mass.:
459.577
SMILES:
CN[C@@H]1COc2cc(F)c(cc2[C@H]1Cc1ccccc1)N1CC(C1)NS(=O)(=O)CC1CC1
Structure:
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