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Target
72 kDa type IV collagenase
Ligand
BDBM256139
Substrate
n/a
Meas. Tech.
Activity Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
35000±n/a nM
Comments
extracted
Citation
 Ferdinandy, P; Csont, TB; Csonka, C; Kedvesné Kupai, K; Kovács, L; Kis-Tamás, A; Takács, FT; Kónya, D; Medgyes, G; Cseh, S; Hajdú, I; Lörincz, Z; Dormán, G; Görbe, A Inhibitors of matrix metalloproteinases US Patent  US9487462 Publication Date 11/8/2016 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM256139
Synonyms:
US9487462, 22
Type:
Small organic molecule
Emp. Form.:
C32H28FN3O3
Mol. Mass.:
521.5814
SMILES:
OC(=O)c1c[nH]c(CN(Cc2ccc(F)cc2)Cc2ccc(OC(c3ccccc3)c3ccccc3)cc2)n1
Structure:
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