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Target
Complement factor D
Ligand
BDBM256239
Substrate
n/a
Meas. Tech.
Human Complement Factor D Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
6±n/a nM
Comments
extracted
Citation
 Altmann, E; Hommel, U; Lorthiois, EL; Maibaum, JK; Ostermann, N; Quancard, J; Randl, SA; Rogel, O; Vulpetti, A; Flohr, S Complement pathway modulators and uses thereof US Patent  US9487483 Publication Date 11/8/2016 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM256239
Synonyms:
US9487483, 91
Type:
Small organic molecule
Emp. Form.:
C23H26Cl2N4O3
Mol. Mass.:
477.384
SMILES:
CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@@H]2CCCC(Cl)(Cl)C2)c2ccccc12 |r|
Structure:
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