Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM256419
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Temperature
310.15±n/a K
Ki
5.9±n/a nM
Comments
extracted
Citation
 Galley, G; Norcross, R; Pflieger, P Pyrazole carboxamide compounds and uses thereof US Patent  US9487501 Publication Date 11/8/2016 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM256419
Synonyms:
US9487501, 20
Type:
Small organic molecule
Emp. Form.:
C19H18ClN5O2
Mol. Mass.:
383.832
SMILES:
Clc1cc(ccn1)-n1cc(cn1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1 |r|
Structure:
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