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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM256882
Substrate
n/a
Meas. Tech.
Fluorescent Imaging Plate Reader (FLIPR) Assay
Temperature
310.15±n/a K
IC50
35±n/a nM
Comments
extracted
Citation
 Fieldhouse, C; Glen, A; Robinson, JS; Fujimoto, T Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disorders US Patent  US9493432 Publication Date 11/15/2016 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM256882
Synonyms:
US9493432, 6
Type:
Small organic molecule
Emp. Form.:
C21H22ClN3O3S
Mol. Mass.:
431.936
SMILES:
COc1cccc(OC)c1C(=O)N[C@H]1CCC[C@@H]1Nc1nc2cc(Cl)ccc2s1 |r|
Structure:
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