Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM294343
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
956±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW 2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists US Patent  US9586950 Publication Date 3/7/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM294343
Synonyms:
US9586950, 11 | methyl 4-cyano-2-{[(3R,6R)-1-{[3- fluoro-2-(5-methyl-1,2,4-oxadiazol- 3-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]oxy}pyridine- 3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H22FN5O5
Mol. Mass.:
479.4604
SMILES:
COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2cccc(F)c2-c2noc(C)n2)nccc1C#N
Structure:
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