Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM294359
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
19.3±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW 2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists US Patent  US9586950 Publication Date 3/7/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM294359
Synonyms:
Methyl 4-cyano-2-(((3R,6R)-1-(2-cyclobutylbenzoyl)-6-methylpiperidin-3-yl)oxy)nicotinate | US9586950, 26
Type:
Small organic molecule
Emp. Form.:
C25H27N3O4
Mol. Mass.:
433.4996
SMILES:
COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2C2CCC2)nccc1C#N
Structure:
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