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Target
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
Ligand
BDBM6706
Substrate
ING Peptide
Meas. Tech.
CDK Kinase Inhibition Assay
Temperature
298.15±n/a K
IC50
38±n/a nM
Comments
extracted
Citation
 Al-awar, RS; Ray, JE; Hecker, KA; Joseph, S; Huang, J; Shih, C; Brooks, HB; Spencer, CD; Watkins, SA; Schultz, RM; Considine, EL; Faul, MM; Sullivan, KA; Kolis, SP; Carr, MA; Zhang, F Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors. Bioorg Med Chem Lett 14:3925-8 (2004) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
Synonyms:
CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
G1/S-specific cyclin-E1
Synonyms:
CCNE | CCNE1 | CCNE1_HUMAN
Type:
Enzyme Subunit
Mol. Mass.:
47073.17
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
410
Sequence:
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
  
Inhibitor
Name:
BDBM6706
Synonyms:
1,4,14,24-tetraazaheptacyclo[16.8.1.0^{2,17}.0^{3,11}.0^{5,10}.0^{12,16}.0^{22,27}]heptacosa-2(17),3(11),5(10),6,8,12(16),18(27),19,21-nonaene-13,15-dione hydrochloride | aza-1,7-annulated indole deriv. 12a
Type:
Small organic molecule
Emp. Form.:
C23H16N4O2
Mol. Mass.:
380.3987
SMILES:
O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1n3CCNCc4cccc(c34)c21
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
ING Peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1341.50
Organism:
n/a
Description:
amino acid residues 246-257 from human retinoblastoma 1 protein.
Residue:
12
Sequence:
INGSPRTPRRGQ