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Target
Serine/threonine-protein kinase Nek2 [T175A]
Ligand
BDBM259836
Substrate
n/a
Meas. Tech.
Nek2 Inhibition Assay
pH
7.6±n/a
Temperature
298.15±n/a K
IC50
189±n/a nM
Comments
extracted
Citation
 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent  US9505766 Publication Date 11/29/2016 
Target
Name:
Serine/threonine-protein kinase Nek2 [T175A]
Synonyms:
NEK2 | NEK2A | NEK2_HUMAN | NLK1 | Serine/threonine-protein kinase Nek2 (T175A)
Type:
Enzyme
Mol. Mass.:
51746.94
Organism:
Homo sapiens (Human)
Description:
Full-length human T175A NEK2 (referred to as "NEK2").
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM259836
Synonyms:
US9505766, 40
Type:
Small organic molecule
Emp. Form.:
C20H18N4O4
Mol. Mass.:
378.3813
SMILES:
COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(N)=O)cc12
Structure:
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