Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Nek2 [T175A]
Ligand
BDBM259837
Substrate
n/a
Meas. Tech.
Nek2 Inhibition Assay
pH
7.6±n/a
Temperature
298.15±n/a K
IC50
1140±n/a nM
Comments
extracted
Citation
 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent  US9505766 Publication Date 11/29/2016 
Target
Name:
Serine/threonine-protein kinase Nek2 [T175A]
Synonyms:
NEK2 | NEK2A | NEK2_HUMAN | NLK1 | Serine/threonine-protein kinase Nek2 (T175A)
Type:
Enzyme
Mol. Mass.:
51746.94
Organism:
Homo sapiens (Human)
Description:
Full-length human T175A NEK2 (referred to as "NEK2").
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM259837
Synonyms:
US9505766, 41
Type:
Small organic molecule
Emp. Form.:
C21H20N4O4
Mol. Mass.:
392.4079
SMILES:
CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N
Structure:
Search PDB for entries with ligand similarity: