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Target
Serine/threonine-protein kinase Nek2 [C22A]
Ligand
BDBM259827
Substrate
n/a
Meas. Tech.
Nek2 Inhibition Assay
pH
7.6±n/a
Temperature
298.15±n/a K
IC50
>300000±n/a nM
Comments
extracted
Citation
 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent  US9505766 Publication Date 11/29/2016 
Target
Name:
Serine/threonine-protein kinase Nek2 [C22A]
Synonyms:
NEK2 | NEK2A | NEK2_HUMAN | NLK1 | Serine/threonine-protein kinase Nek2 (C22A)
Type:
Enzyme
Mol. Mass.:
51714.87
Organism:
Homo sapiens (Human)
Description:
C22A P51955
Residue:
445
Sequence:
MPSRAEDYEVLYTIGTGSYGRAQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR
  
Inhibitor
Name:
BDBM259827
Synonyms:
US9505766, 31
Type:
Small organic molecule
Emp. Form.:
C18H19N2O3P
Mol. Mass.:
342.3288
SMILES:
CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N
Structure:
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