Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Proto-oncogene tyrosine-protein kinase Src [S345C]
Ligand
BDBM259853
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2100±n/a nM
Comments
extracted
Citation
Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent US9505766 Publication Date 11/29/2016 More Info.:
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [S345C]
Synonyms:
Proto-oncogene c-Src (S345C) | SRC | SRC1 | SRC_HUMAN
Type:
Enzyme
Mol. Mass.:
59854.66
Organism:
Homo sapiens (Human)
Description:
P12931 (S345C)
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Inhibitor
Name:
BDBM259853
Synonyms:
US9505766, 57
Type:
Small organic molecule
Emp. Form.:
C33H29N7O2
Mol. Mass.:
555.6291
SMILES:
CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12)\C#N
Structure:
