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Target
Ribosomal protein S6 kinase alpha-3 [399-740]
Ligand
BDBM259875
Substrate
n/a
Meas. Tech.
RSK2 Inhibition Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
20.9±n/a nM
Comments
extracted
Citation
 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent  US9505766 Publication Date 11/29/2016 
Target
Name:
Ribosomal protein S6 kinase alpha-3 [399-740]
Synonyms:
ISPK1 | KS6A3_HUMAN | MAPKAPK1B | RPS6KA3 | RSK2 | Ribosomal S6 kinase 2 (RSK-2)
Type:
Enzyme
Mol. Mass.:
38435.14
Organism:
Homo sapiens (Human)
Description:
aa 399-740; RSK2 C-terminal kinase domain (CTD)
Residue:
342
Sequence:
MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
  
Inhibitor
Name:
BDBM259875
Synonyms:
US9505766, 80
Type:
Small organic molecule
Emp. Form.:
C21H20N8O
Mol. Mass.:
400.4365
SMILES:
Cc1ccc(cc1)-c1c(\C=C(/C#N)n2ccnn2)n(CCCO)c2ncnc(N)c12
Structure:
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