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Target
Histamine H4 receptor
Ligand
BDBM294381
Substrate
n/a
Meas. Tech.
HotSpot Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
130±n/a nM
Comments
extracted
Citation
 Ho, PS; Yoon, DO; Han, SY; Lee, WI; Kim, JS; Park, WS; Ahn, SO; Kim, HJ Substituted tricyclic heterocycles as histamine 4 receptor inhibitors US Patent  US9586959 Publication Date 3/7/2017 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM294381
Synonyms:
US9586959, Compound 39
Type:
Small organic molecule
Emp. Form.:
C15H16ClN7
Mol. Mass.:
329.787
SMILES:
Clc1cnc2nc(N3CCNCC3)n3nc(nc3c2c1)C1CC1
Structure:
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