Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM294389
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
300.15±n/a K
IC50
>100000000±n/a nM
Comments
extracted
Citation
 Ho, PS; Yoon, DO; Han, SY; Lee, WI; Kim, JS; Park, WS; Ahn, SO; Kim, HJ Substituted tricyclic heterocycles as histamine 4 receptor inhibitors US Patent  US9586959 Publication Date 3/7/2017 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM294389
Synonyms:
US9586959, Compound 52
Type:
Small organic molecule
Emp. Form.:
C12H10F3N7
Mol. Mass.:
309.2499
SMILES:
NC1CN(C1)c1nc2ncc(cc2n2cnnc12)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: