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Target
Hexokinase-4
Ligand
BDBM260398
Substrate
n/a
Meas. Tech.
Glucokinase Activity Assay
EC50
136.4±n/a nM
Citation
 Lin, S; Parmee, ER; Xu, J 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment US Patent  US9527838 Publication Date 12/27/2016 
Target
Name:
Hexokinase-4
Synonyms:
FLAG-Glucokinase (GK)
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
FLAG-tagged fusion protein
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
1009.95
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
8
Sequence:
DYKDDDDK
  
Component 2
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM260398
Synonyms:
US9527838, 26
Type:
Small organic molecule
Emp. Form.:
C23H24FN6O4PS3
Mol. Mass.:
594.642
SMILES:
CCOP(=O)(Cc1cnc(NC(=O)c2nc(Sc3nncn3C)ccc2Sc2ccc(F)cc2)s1)OCC
Structure:
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