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Target
D-amino-acid oxidase
Ligand
BDBM406221
Substrate
n/a
Meas. Tech.
In Vitro Measurements of human D-Amino Acid Oxidase (DAAO) Activities
IC50
5500±n/a nM
Citation
Tsai, GE; Wang, C; Hsieh, Y D-amino acid oxidase inhibitors and therapeutic uses thereof US Patent US10336724 Publication Date 7/2/2019
More Info.:
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
Inhibitor
Name:
BDBM406221
Synonyms:
6-(((4-chlorophenyl) thio) methyl)-4-oxo-4H-pyran-3-yl 4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylate | US10336724, Compound 14
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2NO4S
Mol. Mass.:
500.394
SMILES:
Clc1ccc(CCc2c[nH]c(c2)C(=O)Oc2coc(CSc3ccc(Cl)cc3)cc2=O)cc1