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Target
D-amino-acid oxidase
Ligand
BDBM406232
Substrate
n/a
Meas. Tech.
In Vitro Measurements of human D-Amino Acid Oxidase (DAAO) Activities
IC50
550±n/a nM
Citation
 Tsai, GE; Wang, C; Hsieh, Y D-amino acid oxidase inhibitors and therapeutic uses thereof US Patent  US10336724 Publication Date 7/2/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM406232
Synonyms:
6-(naphthalen-1-ylmethyl)-3-oxo-2,3-dihydropyridazin-4-yl 3-phenethyl-1H-pyrazole-5-carboxylate | US10336724, Compound 62
Type:
Small organic molecule
Emp. Form.:
C27H22N4O3
Mol. Mass.:
450.4886
SMILES:
O=C(Oc1cc(Cc2cccc3ccccc23)n[nH]c1=O)c1cc(CCc2ccccc2)n[nH]1
Structure:
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